LACTIC ACIDOSIS IN TYPE 2DIABETES PATIENT WITH AND WITHOUT RENAL IMPAIRMENT TREATED WITH METFORMIN

Metformin is a widely used antihyperglycemic agent recommended by both the American Diabetes Association and European for Study of as first-line type 2 diabetes treatment in all patients receiving new diagnosis, regardless age Lactic acidosis (LA) rare event, with an estimated incidence 4.3 cases per 100,000 person-years metformin users LA caused buildup lactic acid bloodstream. It characterized arterial lactate level ?5 mmol/L blood pH ?7.35, occurs when oxygen levels body drop (hypoxia). The occurrence great concern because mortality rate can be high 50% .To determine whether use diabetic various kidney functions associated increased risk (LA). taking who have renal failure. In our study, was CKD stage 1 to 3b patients. Most them were 3. There statistically significant association between stages disease serum level(P<0.05) .There Is gas analysis.